Comedians mark Oprah's final show with punch lines - The Associated Press

David Letterman, whose up-and-down relationship with Winfrey has long been chronicled, earlier lamented not being invited to the farewell gala in Chicago.

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Among the notable comments made on Twitter were these: — "Apparently Oprah is responsible for life on our planet as we know it." — Kevin Nealon.

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Among the notable comments made on Twitter were these: — "Apparently Oprah is responsible for life on our planet as we know it." — Kevin Nealon. — "I miss both Oprah and Osama. Is there a way to pair them up for something?" — Michael Ian Black.

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Comedians mark Oprah's final show with punch lines - The Associated Press